Figure 5. Increased proliferation in Apc^cKO mice when castrated after Tamoxifen-induced Cre induction.

(a) Timeline of tamoxifen treatment and castration for the Tam-Cas group. (b) Confocal mT/mG imaging for Cas-Tam mice, as well as H&E and β-catenin and Ki67 immunostaining of prostate tissues from Apc^flox and Apc^cKO mice in the Tam-Cas group. (c) Quantification of Ki67-positive cells in anterior prostate sections from Apc^flox and Apc^cKO mice; * p = 0.003.