Table 3.

Univariate and multivariate analysis of association of clinicopathologic features with survival time

Variable	Univariate analysis			Multivariate analysis
	Relative risk	95% CI	P value	Relative risk	95% CI	P value
Age at diagnosis	0.996	0.980,1.011	0.583
Gender
Male	1.000(Ref.)	-	-
Female	1.053	0.651,1,702	0.834
Location
Colon	1.000(Ref.)	-	-
Rectum	1.014	0.628,1.638	0.953
Tumor size			0.064
<2 cm	1.000(Ref.)	-	-
2 ~ 5 cm	0.592	0.282,1.245	0.167
>5 cm	1.356	0.798,2.302	0.260
Duke’s phase
A + B	1.000(Ref.)	-	-
C + D	1.460	0.877,2.432	0.146
T stage			0.386
T1	1.000(Ref.)	-	-
T2	1938.169	0.000,>10 5	0.912
T3	2612.435	0.000,>10 5	0.909
T4	3765.785	0.000,>10 5	0.905
N stage			0.010			0.721
N0	1.000(Ref.)	-	-	1.000(Ref.)	-	-
N1	2.202	1.302,3.727	0.003	0.697	0.261,1.859	0.470
N2	1.845	0.921,3.696	0.084	0.649	0.221,1.903	0.431
M stage
M0	1.000(Ref.)	-	-	1.000(Ref.)	-	-
M1	3.430	2.019,5.828	<0.001	1.998	0.432,9.235	0.376
TNM stage			<0.001			0.709
I	1.000(Ref.)	-	-	1.000(Ref.)	-	-
II	1.421	0.427,4.734	0.567	1.599	0.479,5.341	0.446
III	2.697	0.804,9.049	0.108	1.846	0.384,8.887	0.444
IV	6.005	1.777,20.296	0.004	#	#	#
Differentiation			0.257
Well	1.000(Ref.)	-	-	1.000(Ref.)	-	-
Moderate	1.606	0.802,3.216	0.181
Poor/unknown	1.794	0.889,3.620	0.103
Ets-1
Negative	1.000(Ref.)	-	-	1.000(Ref.)	-	-
Positive	4.913	2.792,8.645	<0.001	3.903	1.945,7.832	<0.001
αvβ6
Negative	1.000(Ref.)	-	-	1.000(Ref.)	-	-
Positive	3.775	2.324,6.133	<0.001	2.175	1.190,3.974	0.012

#: TNM stage IV is linearly dependent on M stage M1.