Table 2.
Relationship between myocardial damage, inflammation, and severity of coronary artery disease by level of kidney function
| Variables | Group A: | Group B: | Group C: | P value | Post-hoc |
|---|---|---|---|---|---|
| GFR ≥60 | GFR 59-30 | GFR <30 | Significant | ||
| (n = 182) | (n = 103) | (n = 35) | Comparisons* | ||
| In hospital markers | |||||
| Troponin I, median (IQR), ng/mL | 1.2 (0.33-6.46) | 2.3 (0.48-6.51) | 2.9 (0.61-6.27) | 0.052 | A < C |
| CRP, median (IQR), mg/mL | 0.3 (0.17-1-13) | 0.69 (0.23-2.65) | 1.9 (0.73-7.67) | <0.001 | A,B < C |
| Uric acid, median (IQR), mg/mL | 5.9 (4.95-7.2) | 7.5 (6.1-9.4) | 7.2 (5.8-8.3) | <0.001 | A < B,C |
| Angiographic findings, n (%)† | 0.002 | ||||
| No CAD | 14/167 (8.3) | 4/70 (5.7) | 0 | - | |
| 1- and 2-vessel CAD | 99/167 (59.3) | 31/70 (44.3) | 2/12 (16.7) | A > C | |
| 3-vessel CAD | 54/167 (32.3) | 35/70 (50) | 10/12 (83.3) | A < B,C |
*Bonferroni-corrected p value was used for Post-hoc analysis.
Abbreviations: GFR glomerular filtration rate, IQR interquartile range, CRP cross-reactive protein, CAD coronary artery disease.
† In the 249 patients who underwent coronary angiography.