Table 3.

Plasma magnesium quintiles in relation to total ischemic stroke, thrombotic and embolic strokes (RR [95% CI])

Plasma Magnesium, mmol/l
	Quintile 1	Quintile 2	Quintile 3	Quintile 4	Quintile 5	p-trend
Range	0.7 – < 0.82	0.82 – < 0.86	0.86 – < 0.90	0.90 – < 0.95	0.95 – 1.15
Total Ischemic Stroke
Cases/Controls	106/71	77/86	96/113	76/96	104/93
Model 1	1.34 (0.86–2.10)	0.85 (0.55–1.32)	0.75 (0.49–1.15)	0.73 (0.48–1.10)	1.00	0.13
Model 2	1.24 (0.78–1.98)	0.81 (0.51–1.28)	0.75 (0.48–1.15)	0.72 (0.47–1.10)	1.00	0.29
Model 3	1.34 (0.82–2.17)	0.86 (0.53–1.38)	0.83 (0.53–1.31)	0.75 (0.48–1.16)	1.00	0.19
Thrombotic Stroke
Cases/Controls	62/44	60/56	60/72	57/67	64/64
Model 1	1.46 (0.84–2.53)	0.11 (0.65–1.90)	0.84 (0.50–1.43)	0.88 (0.54–1.42)	1.00	0.11
Model 2	1.46 (0.83–2.58)	1.03 (0.59–1.81)	0.82 (0.47–1.43)	0.83 (0.50–1.37)	1.00	0.15
Model 3	1.63 (0.89–2.98)	1.09 (0.61–1.95)	0.94 (0.53–1.68)	0.86 (0.51–1.45)	1.00	0.09
Embolic Stroke
Cases/Controls	37/24	15/24	29/36	17/23	31/22
Model 1	1.09 (0.46–2.60)	0.50 (0.21–1.21)	0.58 (0.27–1.24)	0.55 (0.24–1.29)	1.00	0.80
Model 2	0.90 (0.34–2.38)	0.47 (0.18–1.25)	0.64 (0.26–1.56)	0.42 (0.16–1.11)	1.00	0.94
Model 3	1.12 (0.39–3.19)	0.54 (0.20–1.48)	0.74 (0.29–1.90)	0.44 (0.16–1.20)	1.00	0.72

^*Quintiles of magnesium based on distribution in controls

Model 1: Matching factors only (on age, race/ethnicity, smoking, date of blood draw, fasting status, menopausal status and hormone use)

Model 2: Model 1 + alcohol, BMI, physical activity, aspirin, thiazide diuretics

Model 3: Model 2 + HbA1c, History of diabetes, hypertension, CHD and total/HDL cholesterol