FIGURE 2.
Oncogenic C-RAF BxB cooperates with B-RAF in lung tumor growth but not in tumor incidence. A, representative pictures of H&E stained lung sections from DOX-induced (B-RAFΔ/Δ) compound mice and aged-matched controls (B-RAFΔ/wt and B-RAFflox-flox), M, months, red arrows point to lung adenomas. B–D, analysis of tumor incidence, tumor area (μm2) and tumor burden in compound mice (as above, for details on quantification methods see “Experimental Procedures”). Mean values are + S.E.; t test, ns, not significant; *, p < 0.05; ***, p < 0.0005.