FIGURE 4.
Embryonic ablation of B-RAF in alveolar epithelial cells has no effect on lung development and homeostasis. A, representative pictures of H&E stained lung sections from 2-month-old DOX-induced (triple B-RAFΔ/Δ) and controls compound mice (triple B-RAFflox-flox). B, representative pictures of paraffin-embedded lung sections from 2-month-old DOX-treated (triple B-RAFΔ/Δ), and controls animals (triple B-RAFflox-flox) that were stained with the indicated markers (brown), red arrowheads point to B-RAF-positive alveolar cells, green arrowheads point to Ki67-positive alveolar cells. B indicates bronchioles. Hematoxylin was used as a counterstain.