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. 2014 Aug 11;289(39):26847–26858. doi: 10.1074/jbc.M114.590554

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — Induction of colonic HO-1 by hemin ameliorates DSS-induced colitis. Colitis was induced in BALB/c mice using DSS as described under “Experimental Procedures.” A, qRT-PCR analysis of HO-1 mRNA in colons isolated from four groups. Data are presented as mean ± S.D. B, Western blot analysis of HO-1 protein in colons extracted from four groups. β-Actin was used as loading control. C, the analysis of HO-1 activity in colons extracted from four groups. Data are presented as mean ± S.D. D, disease activity index scores of each group. Data are presented as mean ± S.D. E, histological analysis of colons isolated from each group. Paraffin-embedded colonic sections were stained with hematoxylin and eosin to observe inflammation (original magnification, × 200). Each symbol in the graph represents an individual mouse (n = 6; *, compared with control group; *, p < 0.05; #, compared with DSS group; #, p < 0.05). All results shown are representative of three independent experiments.