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. 2014 Aug 6;289(39):27235–27245. doi: 10.1074/jbc.M114.557835

FIGURE 1.

FIGURE 1.

Vildagliptin promotes revascularization following hindlimb ischemia in mice. A, representative images of LDBF for wild-type (WT) mice subjected to surgery-induced hind limb ischemia and treated with vildagliptin or vehicle. B, quantitative analysis of the ischemic/normal LDBF ratio in the vildagliptin or vehicle-treated mice on postoperative days 3, 7, 14, and 21 (n = 10 in each group). *, p < 0.05 versus vehicle control. C, microscopic photographs of capillary density in ischemic adductor muscles 21 days after surgery. Capillaries were immunostained with anti-CD31 antibody. Red, CD31; blue, DAPI. Scale bar, 50 μm. D, quantitative analysis of the capillary density of ischemic muscles in vildagliptin or vehicle-treated mice (n = 5). Results are presented as mean ± S.D. N.S, not significant.