TABLE 1.

Selected murine P0 dental epithelial markers were identified by RNA-seq and DNA microarrays and compared with dental mesenchyme gene expression

RNA-seq experiments identified gene expression changes of the epithelial cell markers in converted oral epithelial (epi.) cells and dental mesenchyme (mes.) cells. Shown are selected murine dental epithelial genes in P0 mouse dental epithelium compared with mesenchymal cells; converted oral epithelial (LS-8) cells compared with non-transformed oral epithelial (LS-8) cells; and converted dental mesenchymal (MDPC) cells compared with non-transformed dental mesenchymal (MDPC) cells. exp., expression.

Gene	Expression levels	P0 dental mes. vs. P0 dental epi.	Converted cells vs. oral epi. cells	Converted cells vs. dental mes. cells
Tbx5	High exp.	(−) 15-fold	(+) 2-fold or less	(+) 4.1-fold
Satb1	Med. exp.	( − ) 2 − fold	(+) 2-fold or less	(+) 10-fold
Pitx1	High exp.	(−) 7-fold	(+) 2-fold or less	(+) 18-fold
Lhx6	Med. exp.	(−) 8.5-fold	(+) 2-fold or less	(+) 2.1-fold
Isl1	High exp.	(−) 6.3-fold	(+) 2-fold or less	(+) 10.4-fold
Dach1	Med. exp.	(−) 2.7-fold	(+) 2-fold or less	(+) 7.9-fold
Atf2	Med. exp.	(−) 4.1-fold	(+) 2-fold or less	(+) 2.8-fold
Lef1	Med. exp.	(−) 2.4-fold	(+) 2-fold or less	(+) 15.4-fold
Hmx1	Low exp.	(−) 3.2-fold	(+) 2-fold or less	(+) 10.8-fold
Tbx1	High exp.	(−) 5.5-fold	(+) 2-fold or less	(+) 2-fold or less
Foxj3	High exp.	(−) 10-fold	(+) 2-fold or less	(+) 6.2-fold
Irf6	High exp.	(−) 7-fold	(+) 2-fold or less	(+) 2-fold or less
Cacna1g	High exp.	(−) 9-fold	(+) 1.4-fold	(+) 2-fold or less
Gadd45a	High exp.	(−) 2.6-fold	(+) 2.3-fold	(+) 2-fold or less
Mmp20	Low exp.	(−) 1.6-fold	(+) 2-fold or less	(+) 2.1-fold
Enam	High exp.	(−) 11-fold	(+) 2-fold or less	(+) 2-fold or less