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. Author manuscript; available in PMC: 2015 Aug 26.
Published in final edited form as: Oncogene. 2014 Mar 24;34(9):1073–1082. doi: 10.1038/onc.2014.61

Figure 2.

Figure 2

BCL6 binds to specific genomic sites in breast cancer cells. (A) ChIP was performed in SK-BR-3 cells for BCL6 binding to target sites identified in lymphoma cells. Data are expressed as BCL6 binding relative to background (at a nonbinding region). (B) De novo motif analysis of genomic sequences associated with BCL6 binding sites in breast cancer cells identified the BCL6 binding motif. (C) Genomic distribution of BCL6 binding sites relative to genes in breast cancer cells. (D) BCL6 ChIP was performed in three different breast cancer cell lines, and binding of BCL6 to binding sites was analyzed by qPCR. (E) Genes containing at least one BCL6 binding site were compared from the breast cancer and lymphoma ChIP-seq datasets.