Table 1.
Examples of clinical stage nanotechnology-based products for antimicrobial management
| Name | Company/Sponsor | Composition | Application | Stage of Development |
|
|---|---|---|---|---|---|
| Diagnosis | Verigene | Nanosphere | Oligonucleotide-conjugated Au nanoparticle |
Bacterial infection and drug resistance diagnosis |
Marketed |
| T2 Candida | T2 Biosystems | Oligonucleotide-conjugated SPION |
Blood detection for sepsis (candidemia) |
Clinical trial | |
| Drug Delivery |
Abelcet | Enzon Pharmaceutical |
Amphotericin B-lipid complex |
Fungal infection | Marketed |
| AmBisome | Gilead Sciences | Liposomal Amphotericin B | Fungal infection | Marketed | |
| Amphotec | Kadmon Pharmaceuticals |
Liposomal Amphotericin B | Fungal infection | Marketed | |
| Fungisome | Lifecare Innovations |
Liposomal Amphotericin B | Fungal infection | Marketed | |
| Arikace | Insmed | Liposomal amikacin | Chronic pseudomonas aeruginosa infection Pulmonary nontuberculous mycobacterial lung disease |
Clinical trial (phase 3) Clinical trial (phase 2) |
|
| Medical Device |
SilvaSorb | AcryMed | Ag nanoparticle-embedded hydrogel |
Wound dressing | Marketed |
| Acticoat | Smith & Nephew | Nanosilver-coated high- density polyethylene mesh |
Wound dressing | Marketed | |
| KoCarbonAg | Bio-medical Carbon Technology |
Ag nanoparticle-coated carbon fiber cloth and PE membrane |
Wound dressing | Clinical trial | |
| ON-Q SilverSoaker |
I-Flow | Ag nanoparticle-coated polyvinylchloride |
Catheter for the delivery of local anesthetics |
Marketed | |
| VentriGuard | Neuromedex | Ag nanoparticle-embedded nonmetallic porous materials |
Ventricular catheter for cerebrospinal fluid drainage |
Marketed | |
| AGENTO I.C. |
C.R. Bard | Ag nanoparticle-distributed hydrophilic polymer |
Endotracheal tube | Marketed | |
| LogiCathAg Tive |
Smiths | Ag nanoparticle-embedded polyurethane |
Central venous catheter | Marketed | |
| Silverline | Spiegelberg | Ag nanoparticle- and insoluble silver salt- incorporated polyurethane or silicone |
Catheter for internal CSF- drainage |
Marketed | |
| IABN | Hadassah Medical Organization |
Quaternary ammonium poly(ethylene imine) nanoparticle-embedded resin |
Root canal sealer, and dental restorative materials |
Clinical trial (phase 2) |
|
| Vaccine | CAF01 | Statens Serum Institut |
Cationic liposome-based adjuvant |
Tuberculosis | Clinical trial (phase 1 completed) |