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. Author manuscript; available in PMC: 2014 Sep 26.
Published in final edited form as: Cancer Metastasis Rev. 2011 Dec;30(0):397–408. doi: 10.1007/s10555-011-9297-9

Fig. 1.

Fig. 1

Generation of the prostanoids through metabolism of arachidonic acid. Arachidonic acid can be metabolized into different bioactive lipids by one of three distinct signaling pathways; the cyclooxygenase (COX), the lipoxygenase, and the P-450 epoxygenase pathways. The COX-isoforms-COX-1 and COX-2 are responsible for the conversion of AA to PGH2, the first step in the generation of TXA2. Thromboxane synthase (TXA2S) then catalyzes the conversion of the COX product, PGH2 to TXA2