Table 2. Cox regression analyses of association between gene expression (high versus low expression; cutpoint: median) and PFS and OS (N = 51 patients with nsNSCLC).

	Association with PFS			Association with OS
	HR	p-value	FDR	HR	p-value	FDR
Chromosome 16 open reading frame 89 (C16orf89)	0.30	<0.001	0.025	0.34	0.002	0.307
Napsin A	0.37	0.002	0.059	0.38	<0.001	0.307
Surfactant protein B	0.24	<0.001	0.023	0.37	0.002	0.307
Aquaporin 4	0.32	<0.001	0.034	0.30	0.008	0.339
TRAF2- and Nck-interacting kinase	0.28	<0.001	0.023	0.25	0.003	0.339
Lysophosphatidyl-cholineacyl-transferase 1	0.31	<0.001	0.045	0.36	0.001	0.307
IL-1 receptor, type II	2.54	0.004	0.092	2.54	0.005	0.339
NKX2-1 (TTF-1)	0.37	0.001	0.052	0.32	0.004	0.339
ABO glycosyl-transferase	0.38	0.002	0.068	0.33	<0.001	0.168

Derived from mRNA profiling data using the Almac Lung Cancer-DSA microarray (1,030 selected genes) [11]. FDR was calculated across 1,030 genes for each endpoint and biomarker type.

Abbreviations: FDR, False Discovery Rate; HR, hazard ratio; IL, interleukin; mRNA, messenger ribonucleic acid; N, number of patients; NKX2-1, NK2 homeobox 1; nsNSCLC, non-squamous non-small cell lung cancer; OS, overall survival; PFS, progression-free survival; TTF-1, transcription factor 1.