Table 1. A 52-gene signature associated with TFS in the discovery cohort.
Expression data were collected for genes with a Cox score ≥2.5 and ≥−2.5 (FDR <5%). A positive Cox score indicates that higher expression correlates with shorter TFS, whereas lower expression indicates longer TFS time. A negative score indicates that higher expression correlates with longer TFS time, whereas lower expression correlates with shorter TFS time.
| Gene | Gene symbol | Cox score |
|---|---|---|
| Phospholipase B domain containing 1 | PLBD1 | 3.32 |
| Tyrosylprotein sulfotransferase 1 | TPST1 | 3.25 |
| Chromosome 19 open reading frame 59 (mast cell–expressed membrane protein 1) | C19orf59 (MCEMP1) | 3.13 |
| Interleukin-1 receptor, type II | IL1R2 | 3.05 |
| Haptoglobin | HP | 2.91 |
| FMS-related tyrosine kinase 3 | FLT3 | 2.90 |
| S100 calcium-binding protein A12 | S100A12 | 2.89 |
| Lymphocyte-specific protein tyrosine kinase | LCK | −2.50 |
| Calcium/calmodulin-dependent protein kinase IIδ | CAMK2D | −2.50 |
| Nucleoporin 43 kD | NUP43 | −2.51 |
| SLAM family member 7 | SLAMF7 | −2.52 |
| Leucine-rich repeat containing 39 | LRRC39 | −2.52 |
| Inducible T cell costimulator | ICOS | −2.53 |
| CD47 molecule | CD47 | −2.54 |
| Limb bud and heart development | LBH | −2.55 |
| SH2 domain containing 1A | SH2D1A | −2.55 |
| CCR4-NOT transcription complex, subunit 6–like | CNOT6L | −2.56 |
| Methyltransferase-like 8 | METTL8 | −2.56 |
| V-ets erythroblastosis virus E26 oncogene homolog 1 | ETS1 | −2.58 |
| Chromosome 2 open reading frame 27A | C2orf27A | −2.60 |
| Purinergic receptor P2Y, G protein–coupled, 10 | P2RY10 | −2.60 |
| T cell receptor–associated transmembrane adaptor 1 | TRAT1 | −2.61 |
| Butyrophilin, subfamily 3, member A1 | BTN3A1 | −2.62 |
| La ribonucleoprotein domain family, member 4 | LARP4 | −2.63 |
| Tandem C2 domains, nuclear | TC2N | −2.63 |
| G protein–coupled receptor 183 | GPR183 | −2.65 |
| MORC family CW-type zinc finger 4 | MORC4 | −2.67 |
| Signal transducer and activator of transcription 4 | STAT4 | −2.67 |
| Lysophosphatidic acid receptor 6 | LPAR6 | −2.67 |
| Chromosome 7 open reading frame 58 (cadherin- like and PC-esterase domain containing 1) | C7orf58 (CPED1) | −2.68 |
| Dedicator of cytokinesis 10 | DOCK10 | −2.69 |
| Rho GTPase-activating protein 5 | ARHGAP5 | −2.71 |
| Major histocompatibility complex, class II, DPα1 | HLA-DPA1 | −2.72 |
| Baculoviral IAP repeat containing 3 | BIRC3 | −2.73 |
| G protein–coupled receptor 174 | GPR174 | −2.73 |
| CD28 molecule | CD28 | −2.73 |
| Utrophin | UTRN | −2.76 |
| CD2 molecule | CD2 | −2.76 |
| Major histocompatibility complex, class II, DPβ1 | HLA-DPB1 | −2.77 |
| ADP-ribosylation factor–like 4C | ARL4C | −2.78 |
| Butyrophilin, subfamily 3, member A3 | BTN3A3 | −2.79 |
| Chemokine (C-X-C motif) receptor 6 | CXCR6 | −2.81 |
| Dynein cytoplasmic 2 light intermediate chain 1 | DYNC2LI1 | −2.84 |
| Butyrophilin, subfamily 3, member A2 | BTN3A2 | −2.84 |
| IL-2–inducible T cell kinase | ITK | −2.85 |
| Small nucleolar RNA host gene 1 | SNHG1 | −2.94 |
| CD96 molecule | CD96 | −3.03 |
| Guanylate binding protein 4 | GBP4 | −3.03 |
| Sphingosine-1-phosphate receptor 1 | S1PR1 | −3.06 |
| Nucleosome assembly protein 1–like 2 | NAP1L2 | −3.10 |
| Kruppel-like factor 12 | KLF12 | −3.15 |
| Interleukin-7 receptor | IL7R | −3.48 |