Table 2. Genes in “The costimulatory signal during T cell activation” Biocarta pathway associated with TFS in the discovery cohort.

A positive Cox score indicates that higher expression correlates with shorter TFS time, whereas lower expression indicates shorter TFS time. A negative Cox score indicates that higher expression correlates with longer TFS time, whereas lower expression correlates with shorter TFS time.

Gene	Gene symbol	Cox score
Growth factor receptor–bound protein 2	GRB2	1.08
CD80 molecule	CD80	0.10
Interleukin-2	IL2	−0.81
Protein tyrosine phosphatase, nonreceptor type 11	PTPN11	−0.92
Cytotoxic T lymphocyte–associated protein 4	CTLA4	−1.85
CD3 molecule, ε (CD3-TCR complex)	CD3E	−1.90
CD3 molecule, δ (CD3-TCR complex)	CD3D	−1.99
Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit α	PIK3CA	−2.06
Major histocompatibility complex, class II, DRα	HLA-DRA	−2.22
T cell receptor α locus	TRA@	−2.35
Major histocompatibility complex, class II, DRβ1	HLA-DRB1	−2.37
Phosphoinositide-3-kinase, regulatory subunit 1 (α)	PIK3R1	−2.37
CD247 molecule	CD247	−2.45
CD3 molecule, γ (CD3-TCR complex)	CD3G	−2.59
CD86 molecule	CD86	−2.68
Lymphocyte-specific protein tyrosine kinase	LCK	−2.77
Inducible T cell costimulator	ICOS	−3.01
CD28 molecule	CD28	−3.12
IL-2–inducible T cell kinase	ITK	−3.20