Table 3. Genes in “The costimulatory signal during T cell activation” Biocarta pathway associated with TFS in the replication cohort.

A positive Cox score indicates that higher expression correlates with shorter TFS time, whereas lower expression indicates shorter TFS time. A negative score indicates that higher expression correlates with longer TFS time, whereas lower expression correlates with shorter TFS time.

Gene	Gene symbol	Cox score
Growth factor receptor–bound protein 2	GRB2	1.76
Protein tyrosine phosphatase, nonreceptor type 11	PTPN11	0.71
Major histocompatibility complex, class II, DRα	HLA-DRA	0.13
CD86 molecule	CD86	0.11
Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit α	PIK3CA	−0.38
Phosphoinositide-3-kinase, regulatory subunit 1 (α)	PIK3R1	−0.47
Major histocompatibility complex, class II, DRβ1	HLA-DRB1	−0.52
CD247 molecule	CD247	−0.71
Interleukin-2	IL2	−0.71
CD3 molecule, γ (CD3-TCR complex)	CD3G	−0.81
CD80 molecule	CD80	−0.91
T cell receptor α locus	TRA@	−1.39
CD3 molecule, δ (CD3-TCR complex)	CD3D	−1.64
CD3 molecule, ε (CD3-TCR complex)	CD3E	−1.67
Cytotoxic T lymphocyte–associated protein 4	CTLA4	−2.09
IL-2–inducible T cell kinase	ITK	−2.38
Lymphocyte-specific protein tyrosine kinase	LCK	−2.66
Inducible T cell costimulator	ICOS	−2.77
CD28 molecule	CD28	−2.99