Table 2.
Genotype and allele distributions in the control subjects and patients with CAD in the Han population
| Total | Men | Women | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Variants | CAD n (%) | Control n (%) | P Value | CAD n (%) | Control n (%) | P Value | CAD n (%) | Control n (%) | P Value |
| rs4886605(SNP1) | |||||||||
| Genotyping | |||||||||
| CC | 79(20.3%) | 96(23.4%) | 58(19.7%) | 51(22.8%) | 21(22.1%) | 45(24.1%) | |||
| CT | 190(48.8%) | 200(48.7%) | 146(49.7%) | 119(53.1%) | 44(46.3%) | 81(43.3%) | |||
| TT | 120(30.8%) | 115(28.0%) | 0.494 | 90(30.6%) | 54(24.1%) | 0.248 | 30(31.6%) | 61(32.6%) | 0.881 |
| Dominant model | |||||||||
| CC | 79(20.3%) | 96(23.4%) | 58(19.7%) | 51(22.8%) | 21(22.1%) | 45(24.1%) | |||
| TT + CT | 310(79.7%) | 315(76.6%) | 0.297 | 236(80.3%) | 173(77.2%) | 0.4 | 74(77.9%) | 142(75.9%) | 0.713 |
| Recessive model | |||||||||
| TT | 120(30.8%) | 115(28.0%) | 0.494 | 90(30.6%) | 54(24.1%) | 0.248 | 30(31.6%) | 61(32.6%) | |
| CC + CT | 269(69.2%) | 296(72.0%) | 0.373 | 204(69.4%) | 170(75.9%) | 0.102 | 65(68.4%) | 126(67.4%) | 0.86 |
| Additive model | |||||||||
| CT | 190(48.8%) | 200(48.7%) | 146(49.7%) | 119(53.1%) | 44(46.3%) | 81(43.3%) | |||
| CC + TT | 199(51.1%) | 211(51.3%) | 0.959 | 148(50.3%) | 105(46.9%) | 0.434 | 51(53.7%) | 106(56.7%) | 0.632 |
| Allele | |||||||||
| C | 348(44.7%) | 392(47.7%) | 262(44.6%) | 221(49.3%) | 86(45.3%) | 171(45.7%) | |||
| T | 430(55.3%) | 430(52.3%) | 0.236 | 326(55.4%) | 227(50.7%) | 0.127 | 104(54.7%) | 203(54.3%) | 0.918 |
| rs12441817(SNP2) | |||||||||
| Genotyping | |||||||||
| CC | 83(21.3%) | 83(20.2%) | 65(22.1%) | 35(15.6%) | 18(18.9%) | 48(25.7%) | |||
| CT | 205(52.7%) | 199(48.4%) | 154(52.4%) | 121(54.0%) | 51(53.7%) | 78(41.7%) | |||
| TT | 101(26.0%) | 129(31.4%) | 0.235 | 75(25.5%) | 68(30.4%) | 0.141 | 26(27.4%) | 61(32.6%) | 0.153 |
| Dominant model | |||||||||
| TT | 101(26.0%) | 129(31.4%) | 0.235 | 75(25.5%) | 68(30.4%) | 0.141 | 26(27.4%) | 61(32.6%) | |
| CC + CT | 288(74.0%) | 282(68.6%) | 0.09 | 219(74.5%) | 156(69.6%) | 0.222 | 69(72.6%) | 126(67.4%) | 0.367 |
| Recessive model | |||||||||
| CC | 83(21.3%) | 83(20.2%) | 65(22.1%) | 35(15.6%) | 18(18.9%) | 48(25.7%) | |||
| TT + CT | 306(78.7%) | 328(79.8%) | 0.691 | 229(77.9%) | 189(84.4%) | 0.064 | 77(81.1%) | 139(74.3%) | 0.208 |
| Additive model | |||||||||
| CT | 205(52.7%) | 199(48.4%) | 154(52.4%) | 121(54.0%) | 51(53.7%) | 78(41.7%) | |||
| CC + TT | 184(47.3%) | 212(51.6%) | 0.226 | 140(47.6%) | 103(46.0%) | 0.712 | 44(46.3%) | 109(58.3%) | 0.056 |
| Allele | |||||||||
| C | 371(47.7%) | 365(44.4%) | 284(48.3%) | 191(42.6%) | 87(45.8%) | 174(46.5%) | |||
| T | 407(52.3%) | 457(55.6%) | 0.188 | 304(51.7%) | 257(57.4%) | 0.07 | 103(54.2%) | 200(53.5%) | 0.869 |
| rs4646422(SNP3) | |||||||||
| Genotyping | |||||||||
| AA | 270(69.4%) | 286(69.6%) | 206(70.1%) | 152(67.9%) | 64(67.4%) | 134(71.7%) | |||
| AG | 102(26.2%) | 115(28.0%) | 74(25.2%) | 67(29.9%) | 28(29.5%) | 48(25.7%) | |||
| GG | 17(4.4%) | 10(2.4%) | 0.294 | 14(4.8%) | 5(2.2%) | 0.187 | 3(3.2%) | 5(2.7%) | 0.759 |
| Dominant model | |||||||||
| AA | 270(69.4%) | 286(69.6%) | 206(70.1%) | 152(67.9%) | 64(67.4%) | 134(71.7%) | |||
| GG + AG | 119(30.6%) | 125(30.4%) | 0.957 | 88(30.0%) | 72(32.1%) | 0.59 | 31(32.6%) | 53(28.4%) | 0.457 |
| Recessive model | |||||||||
| GG | 17(4.4%) | 10(2.4%) | 0.294 | 14(4.8%) | 5(2.2%) | 0.187 | 3(3.2%) | 5(2.7%) | |
| AA + AG | 372(95.6%) | 401(97.6%) | 0.129 | 280(95.2%) | 219(97.8%) | 0.129 | 92(96.8%) | 182(97.3%) | 0.818 |
| Additive model | |||||||||
| AG | 102(26.2%) | 115(28.0%) | 74(25.2%) | 67(29.9%) | 28(29.5%) | 48(25.7%) | |||
| AA + GG | 287(73.8%) | 296(72.0%) | 0.576 | 220(74.8%) | 157(70.1%) | 0.23 | 67(70.5%) | 139(74.3%) | 0.496 |
| Allele | |||||||||
| A | 642(82.5%) | 687(83.6%) | 486(82.7%) | 371(82.8%) | 156(82.1%) | 316(84.5%) | |||
| G | 136(17.5%) | 135(16.4%) | 0.573 | 102(17.3%) | 77(17.2%) | 0.946 | 34(17.9%) | 58(15.5%) | 0.468 |
| rs1048943(SNP4) | |||||||||
| Genotyping | |||||||||
| CC | 20(5.1%) | 17(4.1%) | 15(5.1%) | 8(3.6%) | 5(5.3%) | 9(4.8%) | |||
| CT | 152(39.1%) | 148(36.0%) | 115(39.1%) | 80(35.7%) | 37(38.9%) | 68(36.4%) | |||
| TT | 217(55.8%) | 246(59.9%) | 0.47 | 164(55.8%) | 136(60.7%) | 0.45 | 53(55.8%) | 110(58.8%) | 0.888 |
| Dominant model | |||||||||
| TT | 217(55.8%) | 246(59.9%) | 164(55.8%) | 136(60.7%) | 53(55.8%) | 110(58.8%) | |||
| CC + CT | 172(44.2%) | 165(40.1%) | 0.244 | 130(44.2%) | 88(39.3%) | 0.26 | 42(44.2%) | 77(41.2%) | 0.626 |
| Recessive model | |||||||||
| CC | 20(5.1%) | 17(4.1%) | 15(5.1%) | 8(3.6%) | 5(5.3%) | 9(4.8%) | |||
| TT + CT | 369(94.9%) | 394(95.9%) | 0.499 | 279(94.9%) | 216(96.4%) | 0.402 | 90(94.7%) | 178(95.2%) | 0.87 |
| Additive model | |||||||||
| CT | 152(39.1%) | 148(36.0%) | 115(39.1%) | 80(35.7%) | 37(38.9%) | 68(36.4%) | |||
| CC + TT | 237(60.9%) | 263(64.0%) | 0.371 | 179(60.9%) | 144(64.3%) | 0.429 | 58(61.1%) | 119(63.6%) | 0.671 |
| Allele | |||||||||
| C | 192(24.7%) | 182(22.1%) | 145(24.7%) | 96(21.4%) | 47(24.7%) | 86(23.0%) | |||
| T | 586(75.3%) | 640(77.9%) | 0.231 | 443(75.3%) | 352(78.6%) | 0.223 | 143(75.3%) | 288(77.0%) | 0.645 |
CAD, coronary artery disease; SNP, single-nucleotide polymorphism.