Table 3.
Genotype and allele distributions in control subjects and patients with CAD in the Uygur population
| Total | Men | Women | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Variants | CAD n (%) | Control n (%) | P Value | CAD n (%) | Control n (%) | P Value | CAD n (%) | Control n(%) | P Value |
| rs4886605(SNP1) | |||||||||
| Genotyping | |||||||||
| CC | 75(25.60%) | 153(37.50%) | 52(24.80%) | 74(36.10%) | 23(27.70%) | 79(38.90%) | |||
| CT | 162(55.30%) | 191(46.80%) | 121(57.60%) | 104(50.70%) | 41(49.40%) | 87(42.90%) | |||
| TT | 56(19.10%) | 64(15.70%) | 0.004* | 37(17.60%) | 27(13.20%) | 0.036* | 19(22.90%) | 37(18.20%) | 0.193 |
| Dominant model | |||||||||
| CC | 75(25.60%) | 153(37.50%) | 52(24.80%) | 74(36.10%) | 23(27.70%) | 79(38.90%) | |||
| TT + CT | 218(74.40%) | 255(62.50%) | 0.001* | 158(75.20%) | 131(63.90%) | 0.012* | 60(72.30%) | 124(61.10%) | 0.073 |
| Recessive model | |||||||||
| TT | 56(19.10%) | 64(15.70%) | 37(17.60%) | 27(13.20%) | 19(22.90%) | 37(18.20%) | |||
| CC + CT | 237(80.90%) | 344(84.30%) | 0.235 | 173(82.40%) | 178(86.80%) | 0.21 | 64(77.10%) | 166(81.80%) | 0.367 |
| Additive model | |||||||||
| CT | 162(55.30%) | 191(46.80%) | 121(57.60%) | 104(50.70%) | 41(49.40%) | 87(42.90%) | |||
| CC + TT | 131(44.70%) | 217(53.20%) | 0.027* | 89(42.40%) | 101(49.30%) | 0.159 | 42(50.60%) | 116(57.10%) | 0.313 |
| Allele | |||||||||
| C | 312(53.24%) | 497(60.91%) | 225(53.57%) | 252(61.46%) | 87(52.41%) | 245(60.34%) | |||
| T | 274(46.76%) | 319(39.09%) | 0.006* | 195(46.43%) | 158(38.54%) | 0.021* | 79(47.59%) | 161(39.66%) | 0.081 |
| rs12441817(SNP2) | |||||||||
| Genotyping | |||||||||
| CC | 43(14.70%) | 45(11.00%) | 30(14.30%) | 20(9.80%) | 13(15.70%) | 25(12.30%) | |||
| CT | 150(51.20%) | 178(43.60%) | 110(52.40%) | 92(44.90%) | 40(48.20%) | 86(42.40%) | |||
| TT | 100(34.10%) | 185(45.30%) | 0.01* | 70(33.30%) | 93(45.40%) | 0.034* | 30(36.10%) | 92(45.30%) | 0.348 |
| Dominant model | |||||||||
| TT | 100(34.10%) | 185(45.30%) | 70(33.30%) | 93(45.40%) | 30(36.10%) | 92(45.30%) | |||
| CC + CT | 193(65.90%) | 223(54.60%) | 0.003* | 140(66.70%) | 112(54.60%) | 0.012* | 53(63.90%) | 111(54.70%) | 0.154 |
| Recessive model | |||||||||
| CC | 43(14.70%) | 45(11.00%) | 30(14.30%) | 20(9.80%) | 13(15.70%) | 25(12.30%) | |||
| TT + CT | 250(85.30%) | 363(89.00%) | 0.151 | 180(85.70%) | 185(90.20%) | 0.156 | 70(84.30%) | 178(87.70%) | 0.449 |
| Additive model | |||||||||
| CT | 150(51.20%) | 178(43.60%) | 110(52.40%) | 92(44.90%) | 40(48.20%) | 86(42.40%) | |||
| CC + TT | 143(48.80%) | 230(56.40%) | 0.048* | 100(47.60%) | 113(55.10%) | 0.126 | 43(51.80%) | 117(57.60%) | 0.368 |
| Allele | |||||||||
| C | 236(40.27%) | 268(32.84%) | 170(40.48%) | 132(32.20%) | 66(39.78%) | 136(33.50%) | |||
| T | 350(59.73%) | 548(67.16%) | 0.004* | 250(59.52%) | 278(67.8%) | 0.013* | 100(60.22% | 270(66.5%) | 0.155 |
| rs4646422(SNP3) | |||||||||
| Genotyping | |||||||||
| AA | 251(85.7%) | 350(85.80%) | 178(84.80%) | 177(86.30%) | 73(88.00%) | 173(85.20%) | |||
| AG | 39(13.30%) | 53(13.00%) | 32(15.20%) | 26(12.70%) | 7(8.40%) | 27(13.30%) | |||
| GG | 3(1.00%) | 5(1.20%) | 0.963 | 0(0.00%) | 2(1.00%) | 0.319 | 3(3.60%) | 3(1.50%) | 0.291 |
| Dominant model | |||||||||
| AA | 251(85.70%) | 350(85.80%) | 178(84.80%) | 177(86.30%) | 73(88.00%) | 173(85.20%) | |||
| GG + AG | 42(14.30%) | 58(14.20%) | 0.965 | 32(15.20%) | 28(13.70%) | 0.647 | 10(12.00%) | 30(14.80%) | 0.546 |
| Recessive model | |||||||||
| GG | 3(1.00%) | 5(1.20%) | 0(0.00%) | 2(1.00%) | 3(3.60%) | 3(1.50%) | |||
| AA + AG | 290(99.00%) | 403(98.80%) | 0.803 | 210(100.00%) | 203(99.00%) | 0.243 | 80(96.40%) | 200(98.50%) | 0.275 |
| Additive model | |||||||||
| AG | 39(13.30%) | 53(13.00%) | 32(15.20%) | 26(12.70%) | 7(8.40%) | 27(13.30%) | |||
| AA + GG | 254(86.70%) | 355(87.00%) | 0.901 | 178(84.80%) | 179(87.30%) | 0.453 | 76(91.60%) | 176(86.70%) | 0.248 |
| Allele | |||||||||
| A | 541(92.32%) | 753(92.28%) | 388(92.38%) | 380(92.68%) | 153(92.17%) | 373(91.87%) | |||
| G | 45(7.68%) | 63(7.72%) | 0.977 | 32(7.62%) | 30(7.31%) | 0.869 | 13(7.83%) | 33(8.13%) | 0.906 |
| rs1048943(SNP4) | |||||||||
| Genotyping | |||||||||
| CC | 5(1.70%) | 11(2.70%) | 3(1.40%) | 5(2.40%) | 2(2.40%) | 6(3.00%) | |||
| CT | 85(29.00%) | 112(27.50%) | 63(30.00%) | 54(26.30%) | 22(26.50%) | 58(28.60%) | |||
| TT | 203(69.30%) | 285(69.90%) | 0.642 | 144(68.60%) | 146(71.20%) | 0.562 | 59(71.10%) | 139(68.50%) | 0.899 |
| Dominant model | |||||||||
| TT | 203(69.30%) | 285(69.90%) | 144(68.60%) | 146(71.20%) | 59(71.10%) | 139(68.50%) | |||
| CC + CT | 90(30.70%) | 123(30.20%) | 0.872 | 66(31.40%) | 59(28.70%) | 0.557 | 24(28.90%) | 64(31.60%) | 0.664 |
| Recessive model | |||||||||
| CC | 5(1.70%) | 11(2.70%) | 3(1.40%) | 5(2.40%) | 2(2.40%) | 6(3.00%) | |||
| TT + CT | 288(98.30%) | 397(97.40%) | 0.387 | 207(98.60%) | 200(97.50%) | 0.452 | 81(97.60%) | 197(97.10%) | 0.797 |
| Additive model | |||||||||
| CT | 85(29.00%) | 112(27.50%) | 63(30.00%) | 54(26.30%) | 22(26.50%) | 58(28.60%) | |||
| CC + TT | 208(71.00%) | 296(72.60%) | 0.651 | 147(70.00%) | 151(73.60%) | 0.408 | 61(73.50%) | 145(71.50%) | 0.724 |
| Allele | |||||||||
| C | 95(16.21%) | 134(16.42%) | 69(16.43%) | 64(15.61%) | 26(15.66%) | 70(17.24%) | |||
| T | 491(83.79%) | 682(83.58%) | 0.916 | 351(83.57%) | 346(84.39%) | 0.748 | 140(84.33%) | 336(82.76%) | 0.647 |
CAD, coronary artery disease; SNP, single-nucleotide polymorphism; *P < 0.05.