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. Author manuscript; available in PMC: 2014 Sep 26.
Published in final edited form as: Proceedings (IEEE Int Conf Bioinformatics Biomed). 2012;2012:1–4. doi: 10.1109/BIBM.2012.6392722

TABLE I.

Top 3 Drugs Simialr with ‘Fluoxetine’

(A)
Given drug Chemical Structure Target
Fluoxetine graphic file with name nihms-404108-t0003.jpg P28223 (5-hydroxytryptamine 2A receptor)
P31645 (Sodium-dependent serotonin transporter)
(B)
Similar Drug (SIM) Drug Chemical Structure (SIMchem) Drug Targe (SIMtarget) Original Use
1 Citalopram
SIM=0.556		 graphic file with name nihms-404108-t0004.jpg
SIMchem=0.66		 P31645
SIMtarge=0.53		 •Alcoholism
•Depressive Disorder
•Diabetic Neuropathies
•Obsessive-Compulsive Disorder
•Tobacco Use Disorder
•Dementia
2 Fluvoxamine
SIM=0.542		 graphic file with name nihms-404108-t0005.jpg
SIMchem=0.59		 P31645
SIMtarge=0.53		 •Depressive Disorder
•Obsessive-Compulsive Disorder
•Panic Disorder
3 Cyclobenzaprine
SIM=0.532		 graphic file with name nihms-404108-t0006.jpg
SIMchem=0.54		 P28223
SIMtarge=0.53		 •Myositis
•Muscle Rigidity
•Pain
•Spasm
•Muscle Cramp
•Muscle Spasticity
•Tetanus