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The ratio of mtDNA L-strand to H-strand transcripts in control, DS, DSAD, and AD brains. A) The correlation of mitochondrial L-strand/ H-strand gene expression ratio with age in all four groups. ND6 gene expression represents the L-stand transcription, and ND2 gene expression represents the H-Strand. B) The L-strand/ H-strand gene expression ratio was reduced in DS, DSAD, and AD brains relative to controls.
