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. Author manuscript; available in PMC: 2014 Sep 26.
Published in final edited form as: J Alzheimers Dis. 2010;20(0 2):S293–S310. doi: 10.3233/JAD-2010-100351

Fig. 7.

Fig. 7

The comparison of AβPP protein and processing products to mtDNA mutation frequency and mtDNA amount in DS, DSAD, and control groups. A) AβPP protein is overexpressed in DS and DSAD brains compared to controls (p = 0.0004, and the values are shown as mean plus SD). B) The correlation of β-secretase activity with mtDNA mutation frequency. The dashed lines show the linear regression of individual groups, whereas the solid black line shows the combination of all three groups. C) The correlation of β-secretase activity with mtDNA amount. The dashed lines show the linear regression of individual groups, whereas the solid black line shows the combination of all three groups. D) The correlation of insoluble Aβ40 levels with mtDNA amount. The only significant correlation was found with DSAD group (r = −0.65, p = 0.02, red dashed lines). E) The correlation of the percent of insoluble Aβ42 over total Aβ (i.e., Aβ40 and Aβ42) with mtDNA amount. The proportion of Aβ42 increased with mtDNA levels in the DSAD group (r = +0.72, p = 0.008, red dashed lines).