Table I.
Subject demographics and clinical outcomes for the 6 studies
| 1st AU (year) | Treatment | Randomisation | Comparison | Patient number | Age [years] | Male (%) | HbA1c [%] | Insulin sensitivity [µmol/kg · min] | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Before | After | Before | After | |||||||
| Myhill (2012) | CAPA for 3 months | Randomised | CAPA initiated early (1 week) vs. CAPA initiated late (1–2 months) | 44 | 66.1 ±8.8 | 61.4 | Median = 6.9 (IQR = 6.1–7.3) | Median = 6.9 (IQR = 6.1–7.4) | N/A | N/A |
| Dawson (2008) | CAPA for 3 months | Non-randomised | Before CAPA vs. after CAPA | 20 | 59.8 ±10.2 | 60 | 7.1 ±1.3 | 7.2 ±1.3 | N/A | N/A |
| West (2007) | CAPA for 3 months | Randomised | CAPA for 3 months vs. placebo | 20 | 57.8 ±10.4 | 100 | 8.5 ±1.8 | N/A | 26.5 ±14.4 | N/A |
| Babu (2005) | CAPA for 1–3 months | Non-randomised | Before CAPA vs. after CAPA | 25 | 50.7 ±9 | 64 | 8.3 ±2.2 | 7.9 ±1.8 | N/A | N/A |
| Harsch (2004) | CAPA for about 3 months | Non-randomised | Before CAPA vs. after CAPA | 9 | 56.3 ±8.2 | 77.8 | 6.4 ±0.7 | 6.3 ±0.6 | 2.98 ±2.62 | 4.38 ±2.94 |
| Brooks (1994) | CAPA for 4 months | Non-randomised | Before CAPA vs. after CAPA | 10 | 50.8 ±9.6 | 70 | 8.9 ±1.5 | 8.9 ±1.2 | 11.4 ±6.2 | 15.1 ±4.6 |
N/A – not available