Table III.
Treatment-related adverse events
| Adverse events | D + P (N = 118) | C + P (N = 118) | ||
|---|---|---|---|---|
| Grade 3 |
Grade 4 |
Grade 3 |
Grade 4 |
|
| n | n | n | n | |
| Neutropenia | 41 | 34 | 33 | 40 |
| Lymphopenia | 1 | 0 | 4 | 0 |
| Thrombocytopenia | 5 | 0 | 2 | 1 |
| Anemia | 8 | 2 | 4 | 0 |
| Dizziness | 0 | 0 | 1 | 0 |
| Fever | 0 | 0 | 2 | 1 |
| Pulmonary infection | 1 | 0 | 2 | 0 |
| Hyperglycemia | 0 | 0 | 2 | 0 |
| Fatigue | 1 | 0 | 1 | 0 |
| Nausea | 0 | 0 | 1 | 0 |
| Vomiting | 2 | 0 | 1 | 0 |
| Alopecia | 2 | 2 | 2 | 1 |
| Anorexia | 0 | 1 | 1 | 0 |
| Hypoproteinemia | 0 | 0 | 1 | 0 |
| Allergic shock | 1 | 1 | 1 | 0 |
| Constipation | 0 | 0 | 1 | 0 |
| Paclitaxel allergy | 2 | 0 | 2 | 0 |
| Flatulence | 0 | 0 | 1 | 0 |
| Cough aggravation | 0 | 0 | 1 | 0 |
| Extremities numbness | 1 | 0 | 1 | 0 |
| Diarrhea | 1 | 0 | 0 | 1 |
| Rash | 0 | 0 | 1 | 0 |
| Pruritus | 0 | 0 | 0 | 1 |
| ALT↑ | 1 | 0 | 1 | 0 |
| γ-GT↑ | 0 | 0 | 1 | 0 |
| Muscles or joints pains | 5 | 0 | 3 | 0 |
| Hypokalemia | 0 | 2 | 0 | 0 |
Grade 5 events were not included in this table. Two patients experienced grade 5 events: 1 with asphyxia in the D + P arm and 1 with sudden death in the C + P arm, which were mainly attributed to progression of NSCLC. D + P – dicycloplatin plus paclitaxel, C + P – carboplatin plus paclitaxel