Table 1.
Characteristics of 4,173 patients with osteosarcoma according to tissue of origin.
| Characteristic | Skeletal osteosarcoma (N = 3,917) | ESOS (N = 256) | P value |
|---|---|---|---|
| Mean age (range) | 31.4 years∗ | 60.7 years∗∗ | <0.0001 |
| (0–99 years) | (9–96 years) | ||
| Sex | |||
| Male | 2,175 (55.5%) | 117 (45.7%) | 0.002 |
| Female | 1,742 (44.5%) | 139 (54.3%) | |
| Year of diagnosis | |||
| 1973–1979 | 395 (10.1%) | 9 (3.5%) | <0.0001 |
| 1980–1989 | 609 (15.5%) | 21 (8.2%) | |
| 1990–1999 | 857 (21.9%) | 64 (25%) | |
| 2000–2009 | 2,056 (52.5%) | 162 (63.3%) | |
| Race | |||
| Caucasian | 3,031 (77.8%) | 212 (82.8%) | 0.232 |
| African American | 536 (13.8%) | 30 (11.7%) | |
| Asian | 297 (7.6%) | 12 (4.7%) | |
| Native American | 32 (0.8%) | 2 (0.8%) | |
| Primary site | |||
| Lower extremity | 2,392 (62.6%) | 80 (32.7%) | <0.0001 |
| Upper extremity | 467 (12.2%) | 18 (7.3%) | |
| Head | 398 (10.4%) | 18 (7.3%) | |
| Spine | 114 (3%) | 1 (0.4%) | |
| Ribs/sternum | 105 (2.8%) | 0 | |
| Pelvis | 343 (9%) | 31 (12.7%) | |
| Thorax | 0 | 70 (28.6%) | |
| Abdomen/retroperitoneum | 0 | 27 (11%) | |
| Primary tumor location | |||
| Axial | 961 (25.1%) | 154 (61.1%) | <0.0001 |
| Appendicular | 2,870 (74.9%) | 98 (38.9%) | |
| Regional lymph node | |||
| Present | 61 (2.4%) | 13 (7.7%) | <0.0001 |
| Absent | 2,519 (97.6%) | 155 (92.3%) | |
| Stage | |||
| Distant metastasis | 794 (22.3%) | 43 (18.6%) | 0.188 |
| No distant metastasis | 2,763 (77.7%) | 188 (81.4%) | |
| Tumor size | |||
| <10 cm | 1,252 (63.1%) | 113 (58.9%) | 0.241 |
| ≥10 cm | 731 (36.9%) | 79 (41.1%) | |
| Radiation use | |||
| No | 3,374 (87.7%) | 186 (74.7%) | <0.0001 |
| Yes | 473 (12.3%) | 63 (25.3%) | |
| Histologic type | |||
| Osteosarcoma NOS | 3,322 (84.8%) | 239 (93.4%) | 0.016 |
| Fibroblastic OS | 263 (6.7%) | 10 (3.9%) | |
| Telangiectatic OS | 128 (3.3%) | 3 (1.1%) | |
| OS in Paget's | 79 (2%) | 0 | |
| Small cell OS | 30 (0.8%) | 2 (0.8%) | |
| Central OS | 42 (1.1%) | 1 (0.4%) | |
| Periosteal OS | 40 (1%) | 0 | |
| High grade surface OS | 13 (0.3%) | 1 (0.4%) |
OS: osteosarcoma; ESOS: extraskeletal osteosarcoma; NOS: not otherwise specified; totals for each variable may vary due to missing data but percentages reflect the represented data.
∗Median age is 20 years. ∗∗Median age is 64 years.