Table 2.

Univariate and multivariate prognostic factors for overall survival in a cohort of patients with extraskeletal osteosarcoma.

	Univariate hazard ratio   (95% confidence interval)	Univariate P value	Multivariate hazard ratio   (95% confidence interval)	Multivariate P value
Distant metastasis	3.16   (2.11–4.73)	<0.0001	2.39   (1.34–4.25)	0.003
Tumor size ≥10 cm	2.03    (1.40–2.95)	<0.0001	2.11   (1.41–3.17)	<0.0001
Axial tumor	1.98   (1.39–2.80)	<0.0001	1.65   (1.08–2.53)	0.021
Age  18–32 years  33–59 years  60–99 years	Reference  1.30 (0.63–2.70)   2.59 (1.31–5.12)	0.477   0.006	Reference   1.13 (0.45–2.79) 2.53 (1.08–5.90)	0.796  0.032
Regional lymph node present	2.09  (1.14–3.83)	0.017	Not tested	Not tested
Male gender	1.32  (0.96–1.80)	0.086	Not tested	Not tested
Year of diagnosis  1973–1979  1980–1989  1990–1999  2000–2009	1.80 (0.87–3.75)   0.80 (0.44–1.45)   0.85 (0.59–1.23)   Reference	0.115   0.465 0.390	Not tested	Not tested