Table 1.

Overview of the clinical trials that have used barrier products to decrease acute radiation-induced skin reactions

Product	Control	Patient numbers	Scale	Results	Reference
Mepilex Lite	Aqueous cream	24	RISRAS	30% decrease in erythema	21
Mepilex Lite	Aqueous cream	74	RISRAS/RTOG	40% decrease in overall skin reaction severity	26
Mepilex Lite	Mild salt washes	88	RISRAS	Decrease in moist desquamation healing times from 23 to 16 days	27
Mepitel film	Aqueous cream	78	RISRAS	92% decrease in overall skin reaction severity, decrease in moist desquamation from 26% to 0%	22
Cavilon no sting barrier film	Sorbolene	61	RTOG	Decrease in incidence on moist desquamation from 46% to 33%	28
Cavilon moisturising durable barrier cream	Sorbolene	333	CTCAE v3	No difference between treatment and control arms	29

RISRAS, radiation-induced skin reaction assessment scale; RTOG, Radiation Therapy Oncology Group; CTCAE v3, common terminology criteria for adverse events version 3.