Table 4. Changes in Brain Expression with CCI and mHW: Molecular Function.

Molecular FunctionPositive Z-score	# Affected Genes	# in Gene Set	Z-Score
Methyl Indole-3-acetate Esterase Activity	3	7	12.01
Methyl Jasmonate Esterase Activity	3	7	12.01
Methyl Salicylate Esterase Activity	3	7	12.01
Neuropeptide Receptor Binding	3	21	6.65
Hormone Activity	6	118	4.97
Carboxylesterase Activity	5	97	4.58
Serine Hydrolase Activity	7	203	4.00
G-protein-coupled Receptor Binding	6	183	3.55
Serine-type Peptidase Activity	6	200	3.28
Serine-type Endopeptidase Activity	5	155	3.19
Sodium Ion Transmembrane Transporter Activity	3	80	2.80
Cytokine Activity	5	183	2.75
Acyltransferase Activity	5	193	2.61
Transferace Activity, Transferring Acyl Groups Other Than Amino-acyl Groups	5	193	2.61
Transmembrane Transporter Activity	14	835	2.59
Channel Activity	8	388	2.58
Receptor Binding	16	999	2.58
Passive Transmembrane Transporter Activity	8	389	2.57
Transferase Activity, Transferring Acyl Groups	5	198	2.54
Transporter Activity	16	1026	2.47
Monovalent Inorganic Cation Transmembrane Transporter Activity	4	149	2.41
Ion Transmembrane Transporter Activity	11	654	2.30
Substrate-specific Transmembrane Transporter Activity	12	754	2.20
Substrate-specific Channel Activity	7	376	2.11
Substrate-specific Transporter Activity	13	863	2.09
Negative Z-score
Adenyl Nucleotide Binding	4	1446	−2.49
Adenyl Ribonucleotide Binding	4	1439	−2.48
ATP Binding	4	1414	−2.44
Nucleotide Binding	9	2096	−2.26
Nucleic Acid Binding	12	2510	−2.22
Purine Ribonucleoside Triphosphate Binding	7	1718	−2.13
Binding	77	10525	−2.03

Categories listed consisted of a minimum of 6 genes, had at least 3 genes that were changed, and a Z-score of ≥2.0.