Table 1.

Risk of death in relation to demographic, clinical, hemodynamic and biochemical baseline assessment

A: Single parameter cox regression analysis for clinical, biochemical and hemodynamic parameters, including copeptin
	Single model
Parameter	HR (CI)	p-value
Age (per 5 years↑)	1.0 (0.9 – 1.1)	0.464
Gender	1.3 (0.6 – 2.5)	0.521
6MWD (30 m↓)	1.3 (1.1- 15)	0.001
NYHA	2.4 (1.2 –3.4)	0.012
Edema	1.0 (0.5 – 1.2)	0.835
S-Na (1 mmol/l ↓)	1.1 (1.1 – 1.2)	0.023
Creatinine (per 10 μg/l ↑)	1.0 (1.0 – 1.2)	0.015
eGFR (CKD-EPI) (per 10 ml/min ↓)	1.4 (1.2 – 2.2)	0.013
NT-proBNP (per 100 pg/ml ↑)	1.2 (1.1 -1.5)	0.019
Copeptin (per 5 pmol/l ↑)	1.9 (1.4 – 2.4)	0.001
RA (per 1 mmHg ↑)	1.2 (1.0 – 1.4)	0.040
mPAP (per 5 mmHg ↑)	1.0 (0.8 – 1.4)	0.081
CI (0.5 ml/min/m2 ↓)	1.3 (1.2 – 1.6)	0.018
PVR (50 dyn · sec · cm-5 ↑)	1.1 (0.9 – 1.2)	0.105
SvO2 (-5% ↓)	1.3 (1.1 – 1.3)	0.017
B: Stepwise forward cox regression analysis for biochemical variables including copeptin
	Stepwise forward model for clinical variables including copeptin
Parameter	HR (CI)	p-value
S-Na (1 mmol/l ↓)	1.0 (0.9 – 1.2)	0.796
Creatinine (per 10 μg/l ↑)	0.7 (0.5 – 1.1)	0.819
eGFR (CKD-EPI) (per 10 ml/min ↓)	0.9 (0.9 – 1.0)	0.129
NT-proBNP (per 100 pg/ml ↑)	0.9 (0.8 – 1.2)	0.581
Copeptin (per 5 pmol/l ↑)	1.4 (1.1 -2.0)	0.015

Data are from the retrospective cohort (cohort 1).

Estimated HRs, 95% CIs, and p values were calculated by simple and forward Cox regression analyses.

Definition of abbreviations: 6MWD 6 minute walking distance, NYHA New York Heart Association, S-Na Serum Sodium concentration, eGFR (CKD-EPI) estimated glomerular filtration calculated according the Chronic Kidney Disease Epidemiology Collaboration formula, NT-proBNP N-terminal prohormone of brain natriuretic peptide, RA right atrial pressure, mPAP mean pulmonary artery pressure, CI cardiac index, PVR pulmonary vascular resistance, SvO₂ mixed venous oxygen saturation.