Table 4.
Correlations of serum copeptin levels and serum NT-proBNP levels with demographic, clinical, biochemical and hemodynamic parameters
| Copeptin | NT-proBNP | |||
|---|---|---|---|---|
| Parameter |
rho |
p |
rho |
p |
| Age (years) |
0.21 |
0.05 |
0.18 |
0.21 |
| Gender (female%) |
0.13 |
0.09 |
-0.85 |
0.49 |
|
6MWD [m] |
-0.26 |
0.04 |
-0.51 |
0.01 |
|
NYHA class |
0.46 |
0.01 |
0.29 |
0.04 |
| Edema |
0.06 |
0.48 |
0.168 |
0.18 |
| S-Na [mmol/l] |
0.19 |
0.45 |
-0.03 |
0.83 |
|
Creatinine [μg/l] |
0.39 |
0.01 |
0.32 |
0.01 |
|
eGFR (CKD-EPI) [ml/min] |
-0.32 |
0.01 |
-0.40 |
0.03 |
|
NT-proBNP [pg/ml] |
0.49 |
0.01 |
- |
- |
| Copeptin [pmol/l] |
- |
- |
0.49 |
0.01 |
| RA [mmHg] |
0.19 |
0.06 |
0.41 |
0.01 |
| PCWP |
0.09 |
0.41 |
0.23 |
0.14 |
| mPAP [mmHg] |
0.06 |
0.91 |
0.23 |
0.07 |
| CI [ml/min/m2] |
-0.14 |
0.18 |
-0.51 |
0.01 |
| PVR [dyn · sec · cm-5] |
0.06 |
0.57 |
0.35 |
0.01 |
| SvO2 [%] | -0.22 | 0.07 | -0.60 | 0.01 |
Data are from the retrospective cohort (cohort 1).
The relations between copeptin and NT-proBNP levels and baseline variables were assessed by Spearman rank correlation coefficients.
Significant correlations are highlighted in boldface.
Definition of abbreviations: 6MWD 6 minute walking distance, NYHA New York Heart Association, S-Na Serum Sodium concentration, eGFR (CKD-EPI) estimated glomerular filtration calculated according the Chronic Kidney Disease Epidemiology Collaboration formula, NT-proBNP N-terminal prohormone of brain natriuretic peptide, RA right atrial pressure, PCWP pulmonary capillary wedge pressure, mPAP mean pulmonary artery pressure, CI cardiac index, PVR pulmonary vascular resistance, SvO2 mixed venous oxygen saturation.