Table 3.
Comparison of various parameters according to the need for glucocorticoid administration
| |
Improved without glucocorticoid |
Glucocorticoid needed |
P
value |
||||
|---|---|---|---|---|---|---|---|
| (N = 18) | (N = 29) | ||||||
| |
|
|
[n] |
|
|
[n] |
|
| Age (years) |
68.5 |
(34-84) |
[18] |
68.0 |
(36-80) |
[29] |
N.S. |
| Sex (male/female) |
13/5 |
|
[18] |
17/12 |
|
[29] |
N.S. |
| Smoking (s/ex/n) |
1/12/5 |
|
[18] |
4/16/9 |
|
[29] |
N.S. |
| HRCT patterns |
|
|
[18] |
|
|
[29] |
0.05 |
| OP |
3 |
|
|
1 |
|
|
|
| NSIP |
11 |
|
|
13 |
|
|
|
| HP |
4 |
|
|
7 |
|
|
|
| DAD |
0 |
|
|
8 |
|
|
|
| Mortality rate at 30 days (%) |
0.0 |
|
|
10.3 |
|
|
N.S. |
| Hematologic data |
|
|
|
|
|
|
|
| WBC (/mm3) |
6300 |
(3500-14600) |
[18] |
7400 |
(3500-20800) |
[28] |
N.S. |
| Hb (g/dL) |
12.3 |
(8.5-14.3) |
[18] |
10.9 |
(7.9-16.2) |
[28] |
N.S. |
| Plt (×104/mm3) |
21.5 |
(12.5-34.1) |
[18] |
25.3 |
(8.9-46.9) |
[28] |
N.S. |
| Serum markers |
|
|
|
|
|
|
|
| KL-6 (U/mL) |
601.0 |
(264-2115) |
[16] |
531.5 |
(144-3884) |
[26] |
N.S. |
| SP-A (ng/mL) |
52.0 |
(35.9-141) |
[15] |
89.8 |
(43.2-310) |
[21] |
0.02 |
| SP-D (ng/mL) |
158.0 |
(23-653) |
[15] |
175.0 |
(33-753) |
[25] |
N.S. |
| HSP47 (pg/mL) |
460.2 |
(61.9-1631) |
[18] |
1023.0 |
(100.5-2843.9) |
[29] |
0.003 |
| Respiratory parameters |
|
|
[17] |
|
|
[27] |
|
| P/F ratio (mmHg) |
409.0 |
(260-542.8) |
|
307.3 |
(71-523.8) |
|
0.005 |
| A-a DO2 (mm/Hg) |
15.9 |
(-9.5-69.1) |
|
37.8 |
(-11.4-474.7) |
|
0.007 |
| BAL fluid findings |
|
|
[16] |
|
|
[24] |
|
| Total cell count (×105/mL) |
4.4 |
(1.44-15.5) |
|
5.4 |
(1.27-54.9) |
|
N.S. |
| Macrophages (%) |
65.3 |
(4.3-85.4) |
|
37.3 |
(4-94.8) |
|
N.S. |
| Lymphocytes (%) |
26.6 |
(7.7-95.3) |
|
34.8 |
(1.7-82) |
|
N.S. |
| Neutrophils (%) |
3.2 |
(0-13.6) |
|
3.0 |
(0-93.6) |
|
N.S. |
| Eosinophils (%) |
2.1 |
(0-29.9) |
|
1.8 |
(0-50.8) |
|
N.S. |
| CD4/8 ratio | 0.91 | (0.14-7.05) | 1.59 | (0.14-10.4) | N.S. | ||