Table 1.

Compounds selected for functional studies in view of their agonistic properties for the 25 TAS2R receptors identified in humans to date

hTAS2R	1	3	4	5	7	8	9	10	13	14	16	19	20	30	31	38	39	40	41	42	43	45	46	50	60
Chloroquine		10 and 172 ± 29			+			10000									100
Quinine			10		10			10		10					10		10	10			10		10
Denatonium			300			1000		3 and 120 ± 56	30					0.03 and 0.27 ± 0.06			100				300		30 and 240 ± 192
Colchicine			100 and 1025 ± 121														3000						300 and 1580 ± 170
Strychnine					+			3 and 21.8 ± 7.5															0.1 and 0.43 ± 0.02
Diphenidol	100		100		10			30	30	10	100		100	100	3	100	100	30			30		30
Caffeine					300			300		300											300		300
Saccharin						+									170 ± 10						80 ± 60
Ofloxacin							EC50 ≈200
Phenanthroline				100
Erythromycin								300
Dapsone			100					100										30
Flufenamic acid										0.01 and 0.14 ± 0.02
Carisoprodol										100
Malvidin-3-glucoside					6 and 12.6 ± 0.7
Sodium cromoglycate					3000 and 4500 ± 1600								10 and 45 ± 25								3000

The most recent nomenclature was adopted [5,20-24]. Unless otherwise stated, single values (without SEM) represent the threshold concentration, defined as the lowest concentration (μM) that elicited a calcium response in transfected HEK-293 T cells, whereas values presented as mean ± SEM represent the EC₅₀ (μM) [5]. When both threshold concentration and EC₅₀ were available, both values were reported in this order. When no quantitative indicator was available, the symbol “+” indicates agonist property of the compound to the receptor.