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. 2014 Sep 2;42(17):11218–11232. doi: 10.1093/nar/gku782

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — MBD4_MBD shows a modest binding preference for methylated DNA. Steady state response curves are shown for surface plasmon resonance analyses of wild-type MBD4_MBD (upper panel) and mutant MBD4_MBD(Y109F) (lower panel) binding to methylated (green), mismatch (blue), unmethylated (purple) and hydroxymethylated (green) DNA. Both wild-type and mutant MBD4_MBD show a similar modest preference for methylated DNA.