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. 2014 Aug 28;42(17):11119–11135. doi: 10.1093/nar/gku783

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — Structural changes in the helicase and RQC domains of the WRN protein upon HNE adduction. (A and B) Modeled structure of the WRN helicase and RQC domains with HNE modifications. Side chains of Lys577 (A) and Cys727 (B), which undergo HNE addition, are denoted in red using a space-filling model while the ADP residue is shown in magenta. Magnesium ion is marked as a yellow ball. (C and D) Stereo views demonstrating the changes in local architecture around Lys577 (C) and Cys727 (D) after HNE addition. The unmodified and modified proteins are denoted in blue and green, respectively. RMSD_Lys577 and RMSD_Cys727 denote the RMSD between unmodified and HNE adducted Lys577 and Cys727, respectively.