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. 2014 Aug 28;42(17):11119–11135. doi: 10.1093/nar/gku783

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 8. — Changes in molecular surface of helicase and RQC domains of WRN protein upon HNE adduction. Surface representation of WRN electrostatic potential (±25 kT/e, red-negative, blue-positive, gray-neutral) before (A) and after HNE addition to Lys577 (B). A comparison of the vicinity of native (C) and HNE adducted Lys577 (D) show some changes in molecular surface in the proximity of the ATP (ADP) binding pocket. (E) Surface representation of helicase and RQC domains of the WRN protein after orthogonal rotation along the Y-axis of 45° in relation to structure shown in (A). (F) Surface representation of helicase and RQC domains of the WRN protein with HNE attached to Cys727. Detailed views of the vicinity of native (G) and modified (H) Lys727 illustrate changes in charge distribution and reveal surface location of HNE.