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. 2014 Sep 8;42(17):11136–11143. doi: 10.1093/nar/gku796

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Model of the interaction between Ku70 K31 and an abasic site substrate. A and B. A cartoon representation of the human Ku heterodimer interacting with an abasic site substrate was modeled on the structure 1JEY (21). Five amino acids (pink) were appended to the most N-terminal residue resolved in Ku70 (G34), and the DNA altered to have an abasic site centered within a three nucleotide 5′ overhang. A. Ku70 is in green and Ku80 in cyan. The location of candidate nucleophiles identified in Figures 1 and 2 are shown in red. B. Ku70 K31 is shown in stick representation, with the dashed line showing the distance between nuclei predicted to participate in a Schiff base intermediate.