Figure 7.

RA-induced cycles of histone H3K9 methylation, acetylation, recruitment of NCoR1–2, BER, NER and RARE–promoter chromatin loop. Time course of the major modifications of histone H3K9 at the RARE of CASP9 and CYP26A1 genes. The original data are in Figures 2, 5 and 6 and Supplementary Figures S2, S3, S8, S9 and S10. On the ordinate are indicated: i. fold-induction (arbitrary units); ii. the type of assay (ChIP or 3C). The time of RA induction is shown on the abscissa. The bottom panel shows the frequency of loop formation between RARE–promoter of CASP9 gene in cells expressing wild type or LSD1ALA (Supplementary Figure S10d).