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IGFBP-3 and phosphorylation of insulin receptor increased after pioglitazone treatment. For both A and B, data presented include whole retinal analyses of lean (Ctrl), lean + pioglitazone (Ctrl+pio), BBZDR/Wor obese (Diab), and BBZDR/Wor obese + pioglitazone (Diab+pio) animals. A, Western blot results for IGFBP-3; B, Western blot results for IRTyr-1150/1151. *, p < 0.05 versus control; #, p < 0.05 versus diabetic. Data are mean ± S.E.; n = 5 in all groups.A.U., arbitrary units.
