Table 3.
Methylation frequencies of different genes in the overall series and in non recurrent or recurrent tumors
| |
Frequency (%) |
|||
|---|---|---|---|---|
| Gene | Overall series (n = 74) | Non recurrent tumors (n = 38) | Recurrent tumors (n = 36) | P value* |
| CD44 |
1 |
18 |
3 |
0.06 |
| CASP8 |
1 |
3 |
0 |
1 |
| MLH1 (locus 2) |
1 |
3 |
0 |
1 |
| PTEN |
3 |
5 |
0 |
0.49 |
| VHL |
3 |
5 |
0 |
0.49 |
| BRCA1 |
4 |
8 |
0 |
0.24 |
| CHFR |
4 |
5 |
3 |
1 |
| ATM |
5 |
8 |
3 |
0.62 |
| BRCA2 |
5 |
8 |
3 |
0.62 |
| CDKN1B |
5 |
5 |
5 |
1 |
| RARB |
6 |
8 |
6 |
1 |
|
HIC1 |
9 |
16 |
0 |
0.03 |
| FHIT |
10 |
1 |
10 |
1 |
| MLH1 (locus 1) |
11 |
15 |
8 |
0.48 |
| ESR1 |
12 |
16 |
6 |
0.26 |
| TIMP3 |
13 |
18 |
8 |
0.31 |
| TP73 |
14 |
19 |
8 |
0.19 |
| CDKN2A |
14 |
16 |
14 |
1 |
|
GSTP1 |
15 |
26 |
5 |
0.02 |
| DAPK |
17 |
24 |
8 |
0.11 |
| IGSF4 (CADM1) |
21 |
18 |
25 |
0.58 |
| RASSF1 (locus 1) |
23 |
29 |
14 |
0.16 |
| APC |
29 |
34 |
25 |
0.45 |
|
RASSF1(locus2) |
33 |
45 |
19 |
0.03 |
| CDH13 | 50 | 53 | 47 | 0.81 |
*Fisher’s exact test 2-tailed P value (difference between recurrent and non recurrent tumors). Significant genes are highlighted as bold data.