Table 3.
Autism spectrum disorder interactome genes significantly altered by three or more shRNA treatments
|
Gene |
Gene description |
Fold-change |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Fmr1 | Mecp2 | Mef2a | Mef2d | Nlgn1 | Nlgn3 | Pten | Shank3 | ||
|
Camk2a |
Calcium/calmodulin-dependent protein kinase II alpha |
1.69 |
−2.00 |
−1.81 |
−1.65 |
−1.85 |
−1.68 |
−2.53 |
−1.68 |
|
Prmt1 |
Protein arginine N-methyltransferase 1 |
1.55 |
2.32 |
|
2.02 |
1.65 |
2.17 |
1.79 |
2.06 |
|
Cacna1c |
Calcium channel, voltage-dependent, L-type, alpha 1C subunit |
1.68 |
1.75 |
1.69 |
1.90 |
1.64 |
1.67 |
2.23 |
|
|
Sh3gl3 |
SH3-domain GRB2-like 3 |
|
1.59 |
1.70 |
1.62 |
1.59 |
1.63 |
1.84 |
1.56 |
|
R3hdm1 |
R3H domain 1 (binds single-stranded nucleic acids) |
2.40 |
−2.09 |
−1.63 |
1.92 |
|
−1.65 |
−1.88 |
|
|
Tgfb1i1 |
Transforming growth factor beta 1-induced transcript 1 |
|
|
|
−2.96 |
1.74 |
−3.19 |
2.48 |
|
|
Lims2 |
LIM and senescent cell antigen-like domains 2 |
|
2.43 |
|
1.75 |
|
|
3.80 |
1.90 |
|
Kif17 |
Kinesin family member 17 |
−2.01 |
−2.13 |
|
−2.36 |
|
−1.70 |
|
|
|
Nkd2 |
Naked cuticle 2 homolog (Drosophila) |
−1.78 |
−2.12 |
|
−1.83 |
|
−1.77 |
|
|
|
Capn3 |
Calpain 3 |
|
−1.65 |
1.53 |
2.98 |
|
|
−1.77 |
|
|
Nell1 |
NEL-like 1 (chicken) |
2.23 |
−1.85 |
|
−1.58 |
1.64 |
|
|
|
|
PYCR1 |
Pyrroline-5-carboxylate reductase 1 |
−1.56 |
−2.81 |
|
|
|
−2.00 |
1.55 |
|
|
TBC1D9B |
TBC1 domain family, member 9B (with GRAM domain) |
1.94 |
−2.08 |
1.57 |
|
|
|
1.50 |
|
|
Prr13 |
Proline-rich 13 |
−1.81 |
−1.77 |
|
−1.71 |
|
−1.82 |
|
|
|
STK32C |
Serine/threonine kinase 32C |
|
−1.89 |
|
|
|
−1.64 |
−1.69 |
−1.51 |
|
DLGAP2 |
Discs, large (Drosophila) homolog-associated protein 2 |
1.80 |
|
−1.60 |
|
−2.10 |
|
|
|
|
SOD1 |
Superoxide dismutase 1, soluble |
|
|
−1.64 |
|
|
|
−2.22 |
−1.69 |
|
Dlgap1 |
Discs, large (Drosophila) homolog-associated protein 1 |
1.91 |
|
|
−2.45 |
|
|
−1.86 |
|
|
MBD2 |
Methyl-CpG binding domain protein 2 |
|
|
−1.94 |
|
|
−1.58 |
|
−1.55 |
|
FBLN5 |
Fibulin 5 |
1.52 |
2.15 |
|
|
|
|
2.69 |
|
|
Sertad1 |
SERTA domain-containing 1 |
|
|
|
−1.67 |
|
−1.95 |
|
−1.69 |
|
Bhlhe40 |
Basic helix-loop-helix family, member e40 |
|
−2.28 |
|
−1.85 |
|
−1.74 |
|
|
|
Slit2 |
Slit homolog 2 (Drosophila) |
|
−1.68 |
|
−2.43 |
|
|
−2.09 |
|
|
Actn2 |
Actinin alpha 2 |
|
−2.64 |
|
−1.53 |
|
−1.65 |
|
|
|
Ube3a |
Ubiquitin protein ligase E3A |
|
−2.48 |
|
−1.52 |
|
|
|
−1.53 |
|
Slc13a3 |
Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 |
|
|
|
2.32 |
|
1.56 |
−1.60 |
|
|
NOMO1 |
NODAL modulator 1 |
|
|
1.64 |
|
|
|
1.53 |
1.54 |
|
RALBP1 |
RalA binding protein 1 |
1.65 |
|
1.52 |
|
|
|
1.73 |
|
|
MYH10 |
Myosin, heavy chain 10, non-muscle |
−2.12 |
−1.78 |
|
|
|
|
−1.53 |
|
|
HMG20A |
High-mobility group 20A |
|
1.68 |
1.59 |
|
|
|
1.76 |
|
|
BAIAP2 |
BAI1-associated protein 2 |
|
|
|
|
−1.51 |
−1.73 |
−1.55 |
|
|
Fxr1 |
Fragile X mental retardation gene 1, autosomal homolog |
1.61 |
1.56 |
|
1.99 |
|
|
|
|
|
Lingo1 |
Leucine-rich repeat and Ig domain-containing 1 |
|
|
|
−1.56 |
|
|
−1.73 |
−1.57 |
|
Nup62 |
Nucleoporin 62 |
−1.54 |
|
|
−1.59 |
|
−1.70 |
|
|
|
Notch2 |
Notch gene homolog 2 (Drosophila) |
|
1.69 |
|
1.52 |
|
|
−2.06 |
|
|
EML1 |
Echinoderm microtubule-associated protein-like 1 |
−1.64 |
1.72 |
|
|
|
|
−1.72 |
|
|
NECAB3 |
N-terminal EF-hand calcium-binding protein 3 |
|
−1.79 |
|
|
|
−1.52 |
−1.75 |
|
| Tcf25 | Transcription factor 25 (basic helix-loop-helix) | −1.51 | −1.69 | −1.54 | |||||