Table 5.
Ingenuity pathways that were significantly enriched in multiple ASD short-hairpin (sh)RNA knockdown experiments
| Description | Blank pathway ranking | Fmr1 pathway ranking | Mef2a pathway ranking | Mef2d pathway ranking | Mecp2 pathway ranking | Nlgn1 pathway ranking | Nlgn3 pathway ranking | Pten pathway ranking | Shank3 pathway ranking | Pathway count | Average ranking |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Axonal guidance signaling |
4 |
1 |
16 |
2 |
1 |
2 |
1 |
4 |
1 |
8 |
3.50 |
|
Molecular mechanisms of cancer |
6 |
5 |
2 |
11 |
6 |
1 |
2 |
1 |
6 |
8 |
4.25 |
|
Breast cancer regulation by stathmin1 |
13 |
8 |
1 |
8 |
4 |
3 |
5 |
2 |
|
7 |
4.43 |
|
G-protein coupled receptor signaling |
|
2 |
10 |
5 |
8 |
|
|
9 |
|
5 |
6.80 |
| Protein kinase A signaling |
|
6 |
|
18 |
2 |
|
14 |
3 |
|
5 |
8.60 |
| Huntington’s disease signaling |
|
|
23 |
1 |
37 |
|
|
22 |
3 |
5 |
17.20 |
|
Corticotropin-releasing hormone signaling |
|
|
4 |
9 |
31 |
|
7 |
36 |
|
5 |
17.40 |
| Calcium signaling |
8 |
|
15 |
12 |
44 |
|
|
43 |
11 |
5 |
25.00 |
| Amyotrophic lateral sclerosis signaling |
|
4 |
|
15 |
66 |
|
|
41 |
7 |
5 |
26.60 |
| Synaptic long-term potentiation |
|
|
5 |
6 |
5 |
|
|
6 |
|
4 |
5.50 |
| cAMP-mediated signaling |
|
|
8 |
7 |
3 |
|
|
7 |
|
4 |
6.25 |
| GNRH signaling |
|
|
6 |
20 |
9 |
|
|
13 |
|
4 |
12.00 |
|
Neuropathic pain signaling in dorsal horn neurons |
|
7 |
21 |
3 |
|
|
|
18 |
|
4 |
12.25 |
| Neuroprotective role of THOP1 in Alzheimer’s disease |
7 |
23 |
19 |
|
|
4 |
6 |
|
|
4 |
13.00 |
| Role of NFAT in cardiac hypertrophy | 17 | 7 | 9 | 19 | 4 | 13.00 |