Table 5.
AGRE families with two children with ASD and comorbid epilepsy (n = 11): clinical status, type of seizures and risk factors in all siblings a
| Family | Gender | Autism diagnosis | Type of seizure b | Risk factor of ASD and/or epilepsy |
|---|---|---|---|---|
| AU0025 |
M |
Autism |
Partial |
Mitochondrial disorder, mild tonsillectomy (premature puberty) |
| |
M |
Autism |
Multiple |
No risk reported |
| |
F |
Unaffected |
No seizure |
Unknown |
| AU0051 |
M |
Autism |
Absence |
No risk reported |
| |
M |
Autism |
Absence |
Agenesis of corpus callosum |
| AU0123 |
F |
Autism |
Partial |
Prematurityc/pre- or perinatal insult |
| |
M |
Autism |
Multiple |
Unknown |
| |
F |
Unaffected |
No seizure |
Unknown |
| AU0176 |
F |
Autism |
Partial |
No risk reported |
| |
M |
Autism |
Partial |
No risk reported |
| |
M |
Unaffected |
No seizure |
Unknown |
| |
F |
Unaffected |
No seizure |
Unknown |
| AU0275 |
M |
Autism |
Multiple |
No risk reported |
| |
M |
Autism |
Not indicated |
Unknown |
| |
F |
Unaffected |
No seizure |
Unknown |
| |
F |
Unaffected |
No seizure |
Unknown |
| AU0461 |
M |
Autism |
Generalized |
No risk reported |
| |
M |
Autism |
Generalized |
Unknown |
| AU0548 |
F |
Autism |
Absence |
No risk reported |
| |
M |
Autism |
Not indicated |
No risk reported |
| |
F |
Unaffected |
No seizure |
Unknown |
| AU0731 |
M |
Autism |
Generalized |
Prematurityc/pre- or perinatal insult |
| |
M |
PDD-NOS |
Not indicated |
Unknown |
| AU0765 |
M |
Autism |
Absence |
Unknown |
| |
F |
PDD-NOS |
Not indicated |
t(2;9)(p13;q34.3) |
| |
M |
Unaffected |
No seizure |
Unknown |
| AU0922 |
M |
Autism |
Partial |
No risk reported |
| |
F |
Autism |
Partial |
Unknown |
| AU1208 |
M |
Autism |
Multiple |
15q11–13 duplication |
| M | Autism | Absence | Unknown |
aFrom the 154 families included in the co-segregation analysis, the families with ASD children and without epilepsy are not detailed in this table; bnot indicated means that the type of seizures was not given in the AGRE database, although the patient exhibits epilepsy; cdefined as delivery before 35 weeks of gestational age for single births or before 33 weeks of gestational age for twin births. AGRE, Autism Genetic Resource Exchange; ASD, autism spectrum disorders; PDD-NOS, pervasive developmental disorder-not otherwise specified.