Table 1. MAT Binding Affinities of Top VS Hit Compounds.
Ki (nM) |
||||
---|---|---|---|---|
SERT | DAT | NET | selectivity ratio SERT/DAT/NET | |
TN-01 | 1029 ± 81 | 3058 ± 403a,d | 613 ± 162b,e | 2:5:1 |
TN-05 | 668 ± 41 | >20 000 | 323 ± 53c,d | 2:>62:1 |
TN-06 | >20 000 | 15 740 ± 2787 | 841 ± 225c,e | 24:19:1 |
TN-13 | 12 600 ± 2122 | 780 ± 78a,e | 215 ± 55c,e | 58:4:1 |
SERT vs DAT.
DAT vs NET.
SERT vs NET.
p < 0.005.
p < 0.0005.