Table 2. MAT Substrate Uptake Inhibition Potencies of Top VS Hit Compounds.
IC50 (nM) |
||||
---|---|---|---|---|
SERT | DAT | NET | potency ratio SERT/DAT/NET | |
TN-01 | 5025 ± 1894 | 2562 ± 450 | 2092 ± 291 | 2:1:1 |
TN-05 | 3845 ± 257 | >20 000 | 635 ± 99b,d | 6:>31:1 |
TN-06 | >20 000 | 13 880 ± 4424 | 5574 ± 1607 | >3:2:1 |
TN-13 | 18 870 ± 5566 | 720 ± 174a,c | 615 ± 24b,c | 30:1:1 |
SERT vs DAT.
SERT vs NET.
p < 0.05.
p < 0.005.