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. 2014 Jul 8;5(9):784–792. doi: 10.1021/cn500133b

Table 2. MAT Substrate Uptake Inhibition Potencies of Top VS Hit Compounds.

  IC50 (nM)
  
  SERT DAT NET potency ratio SERT/DAT/NET
TN-01 5025 ± 1894 2562 ± 450 2092 ± 291 2:1:1
TN-05 3845 ± 257 >20 000 635 ± 99b,d 6:>31:1
TN-06 >20 000 13 880 ± 4424 5574 ± 1607 >3:2:1
TN-13 18 870 ± 5566 720 ± 174a,c 615 ± 24b,c 30:1:1
a

SERT vs DAT.

b

SERT vs NET.

c

p < 0.05.

d

p < 0.005.