Figure 3.

(A) A model pathway comprising of two influx arms (I1, I2) and three efflux arms (E1, E2, E3). (B) Pairwise similarity matrix, subject to hierarchical clustering, identifies six distinct clusters. (C) PCA-based clustering of pathway activity measures segregates models into two distinct groups, one that contains models from clusters 5 and 6 and another that contains the remainder of the models. (D) Models in clusters 5 and 6 include the reference model 5 and all other instances when the flux through influx arm I1 and efflux arm E2 is preserved.