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. 2014 Aug 21;42(16):10288–10306. doi: 10.1093/nar/gku722

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Identification of gene–environment interactions in host immunity. (A,B,C) Gene expression of select driver genes identified in tryptophan metabolic pathway (IDO1) and nicotinamide metabolism (CD38, NT5C3). (D,E) Effect of knocking down CD38 and NT5C3 on IL-6 production in response to ex vivo stimulation of PBMCs from healthy individuals with Candida conidia.