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. 2014 Aug 21;42(16):10288–10306. doi: 10.1093/nar/gku722

Table 3.

Top-scoring wound healing response pathways and key driver genes identified by MIPA

Pathway MIPA (P-value) Driver genes GSEA GSOA
Glutathione metabolism 0.0182 Gstm1, Gstm2, Gstm3, Gsta1, Gsta3 Down Down
Cytokine-cytokine receptor interaction 0.0151 Tnfrsf11a, Inhba, Il1b, Cxcl10, Cxcl5, Egfr, Cxcl16, Cxcr4, Osmr Up Up
ErbB signaling pathway 0.0479 Erbb4, Hbegf, Cdkn1a, Egfr Up Up
Histidine metabolism 0.0455 Abp1, Maoa, Hdc N.D. N.D.