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. 2014 Aug 13;42(16):10516–10528. doi: 10.1093/nar/gku746

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — The role of the 9-1-1 complex in stimulating DNA resection. (A, B) The 9-1-1 complex stimulates extensive DNA resection by recruiting Dna2-Sgs1^BLM and Exo1 to sites of resection. Following recruitment by 9-1-1, Dna2-Sgs1^BLM and Exo1 contribute differently to resection. In the presence of Rad9^53BP1(A), extensive resection is more dependent on Exo1 than Dna2-Sgs1^BLM. In the absence of Rad9^53BP1(B), extensive resection is more dependent on Dna2-Sgs1^BLM than Exo1. The set of four filled ellipses represent histone octamers.