Table 16. COSMIC database variants, taking into account the DNA variant and the impact on the gene product.

Variants have been annotated using SETH, thus the variant types delivered by SETH are considered.

Frequency	DNA variant type	Protein variant type
30080 1051 1012 490 351 215 179 171 63 59 53 38 26 19 3 3 1	SUBSTITUTION SUBSTITUTION DELETION UNKNOWN INSERTION DELETION UNKNOWN DELETION INSERTION UNKNOWN UNKNOWN INSERTION UNKNOWN SUBSTITUTION DELETION SUBSTITUTION DUPLICATION	SUBSTITUTION UNKNOWN FRAMESHIFT SUBSTITUTION FRAMESHIFT DELETION UNKNOWN UNKNOWN INSERTION DELETION FRAMESHIFT UNKNOWN INSERTION FRAMESHIFT SUBSTITUTION INSERTION UNKNOWN