Table 3.
Distribution of pancreatic cancer cases and controls, and corresponding odds ratios (ORs) and 95% confidence intervals (CIs), by the use of antidiabetic medications among diabetics with a diagnosis of diabetes 2 or more years before cancer diagnosis (or interview for controls). Data from Pancreatic Cancer Case-Control Consortium (PanC4)
| Cases |
Controls |
ORa (95% CI) | |||
|---|---|---|---|---|---|
| N | % | N | % | ||
| Use of oral antidiabeticsb | |||||
| No | 184 | 23.9 | 185 | 24.4 | 1c |
| Yes | 496 | 64.3 | 543 | 71.7 | 0.92 (0.69–1.23) |
| Missing | 91 | 11.8 | 29 | 3.8 | |
| Duration of oral antidiabetic use (years)d | |||||
| No use | 61 | 17.5 | 42 | 13.4 | 1c |
| <5 | 93 | 26.7 | 94 | 29.9 | 0.79 (0.44–1.41) |
| 5 to <10 | 53 | 15.2 | 74 | 23.6 | 0.56 (0.30–1.05) |
| 10 to <15 | 33 | 9.5 | 40 | 12.7 | 0.57 (0.27–1.18) |
| ≥15 | 21 | 6.0 | 35 | 11.2 | 0.31 (0.14–0.69) |
| Missing | 87 | 25.0 | 29 | 9.2 | |
| P-value for trende | 0.002 | ||||
| Use of insulinf | |||||
| No | 407 | 50.9 | 547 | 68.3 | 1c |
| Yes | 360 | 45.0 | 237 | 29.6 | 2.66 (2.07–3.43) |
| Missing | 33 | 4.1 | 17 | 2.1 | |
| Duration of insulin use (years)g | |||||
| No use | 245 | 48.5 | 456 | 67.7 | 1c |
| <5 | 134 | 26.5 | 58 | 8.6 | 5.60 (3.75–8.35) |
| 5 to <10 | 37 | 7.3 | 43 | 6.4 | 1.87 (1.08–3.23) |
| 10 to <15 | 24 | 4.8 | 41 | 6.1 | 1.66 (0.90–3.06) |
| ≥15 | 24 | 4.8 | 56 | 8.3 | 0.95 (0.53–1.70) |
| Missing | 41 | 8.1 | 20 | 3.0 | |
| P-value for trend | 0.065 | ||||
aPooled ORs were computed from logistic regression models adjusted for study, study center (for multicenter studies), age, sex, race/ethnicity, education, body mass index, tobacco smoking, alcohol drinking, and history of pancreatitis.
bInformation available in the Central Europe, Mayo Clinic, MD Anderson Cancer Center (MDACC), Memorial Sloan Kettering Cancer Center (MSKCC), National Cancer Institute (NCI), Surveillance of Environmental Aspects Related to Cancer (SEARCH), and University of California, San Francisco (UCSF) studies.
cReference category.
dInformation available in the Central Europe, MDACC, and UCSF studies.
eTests for linear trend of the ORs were based on ordinal coding of the categories and the corresponding χ2 statistic.
fInformation available in the Central Europe, Mayo Clinic, MDACC, MSKCC, NCI, SEARCH, UCSF, and University of Minnesota studies.
gInformation available in the Central Europe, MDACC, NCI, SEARCH, and UCSF studies.