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. 2014 Sep 26;5:463. doi: 10.3389/fimmu.2014.00463

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Copyright © 2014 Yeaman, Filler, Schmidt, Ibrahim, Edwards and Hennessey.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Conceptual design of modular and combinatorial convergent vaccine immunogens. Illustrated here is an example of a convergent vaccine immunogen that integrates multiple antigen motifs (Ag motif) containing flanking sequences (Flank) optimized as T-cell epitopes, interposed by strategic linker domains (Link) in a fusion construct. By virtue of its expression in a strategic heterologous system, glycosylation motifs (Glyco motif) or lack thereof would be favored to stimulate or target immune pattern recognition receptors (PRRs) to evoke optimal responses for protective efficacy.